Prescription Required — For external veterinary use only. Apply strictly as directed by a licensed veterinarian. Keep away from eyes, ears, and mucous membranes. Do not allow ingestion — use Elizabethan collar if needed. Keep out of reach of children.
IMPORTANT — Active Ingredient(s) Require Label Verification: Based on the product name “Zemazol-STZ”, the active ingredients are likely Miconazole Nitrate (antifungal — imidazole class) and Silver Sulfadiazine (STZ) (antibacterial — sulfonamide/silver combination). Confirm exact active names, concentrations (%), and any additional actives from the physical Oriheal Zemazol-STZ product label before publishing. Update the Composition section below accordingly.
Oriheal Zemazol-STZ Veterinary Antifungal & Antibacterial Cream for Dogs & Cats (20gm)
Oriheal Zemazol-STZ is a veterinary prescription topical antifungal and antibacterial cream manufactured by Oriheal Lifesciences, formulated for the management of fungal and bacterial skin infections in dogs and cats. The combination of an antifungal agent (likely Miconazole Nitrate) and an antibacterial agent (likely Silver Sulfadiazine — STZ) in a single cream provides dual-action coverage for mixed fungal-bacterial skin infections, which are common in dogs and cats with dermatitis, pyoderma, hot spots, and ringworm. Confirm active ingredient composition from label.
Composition (per gram — confirm from product label before publishing)
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Likely active 1 — Miconazole Nitrate: Antifungal (imidazole class) — inhibits fungal ergosterol biosynthesis; active against dermatophytes (Trichophyton, Microsporum — ringworm), Malassezia pachydermatis (yeast), and Candida spp.; confirm concentration (%) from label
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Likely active 2 — Silver Sulfadiazine (STZ): Broad-spectrum antibacterial; silver ions disrupt bacterial cell membrane and DNA; sulfonamide component inhibits bacterial folate synthesis; active against Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa and Staphylococcus spp.; confirm concentration (%) from label
- Cream base and excipients — confirm from label
Mechanism of Action
- Miconazole (antifungal) — inhibits fungal cytochrome P450-dependent 14α-demethylase, blocking ergosterol biosynthesis and disrupting fungal cell membrane integrity; fungicidal against dermatophytes and Malassezia
- Silver Sulfadiazine (antibacterial) — silver ions bind fungal and bacterial DNA; sulfonamide inhibits para-aminobenzoic acid (PABA) utilisation and folate synthesis in bacteria; effective against Pseudomonas aeruginosa, Staphylococcus intermedius, and other common skin pathogens
- Dual-action combination — covers mixed fungal-bacterial skin infections in a single topical application
Therapeutic Class
- Veterinary topical antifungal + antibacterial combination prescription cream for dogs and cats — fungal and bacterial skin infection, ringworm, Malassezia, pyoderma, and mixed dermatitis management
Indications
- Fungal skin infections — dermatophytosis (ringworm) caused by Trichophyton and Microsporum spp.
- Malassezia pachydermatis (yeast) skin infection and otitis (skin application only)
- Mixed fungal-bacterial skin infections and dermatitis
- Superficial and deep pyoderma with concurrent fungal involvement
- Hot spots (acute moist dermatitis) with secondary fungal or bacterial infection
- Skin fold dermatitis (intertrigo) — facial, vulvar, tail, and body skin folds
- Interdigital furunculosis and pododermatitis with fungal/bacterial component
Directions for Use
- Clean and dry the affected area thoroughly before application — clip hair if necessary to allow cream contact with skin surface
- Apply a thin layer of cream to the affected area as directed by a veterinarian
- Frequency: typically once or twice daily — confirm from label or prescription
- Use Elizabethan collar to prevent licking until cream is fully absorbed
- Continue for full prescribed duration even if lesions appear improved — premature discontinuation leads to recurrence
Safety Information
- Prescription medicine — for veterinary use only; apply under licensed veterinary supervision with confirmed diagnosis
- If Silver Sulfadiazine is confirmed active: use with caution in animals with known sulfonamide hypersensitivity; avoid application over very large body surface areas due to systemic sulfonamide absorption risk
- Silver Sulfadiazine — use with caution in animals with hepatic or renal impairment (systemic absorption risk with large surface area application)
- Do not use on or near eyes, ears, or mucous membranes
- Discontinue if localised irritation, excessive redness, or allergic reaction at application site occurs; consult a veterinarian
- Keep out of reach of children; store in a cool, dry place away from direct sunlight; keep tube tightly closed after use