Vetrina Setcal Calcium Suspension 200ml for Dogs & Cats

VETERINARY USE — For use in dogs and cats under veterinary supervision. Administer as directed by a licensed veterinarian. Shake well before use. Do not exceed recommended dose — calcium oversupplementation can cause hypercalcaemia and soft tissue mineralisation. Keep out of reach of children. Store in a cool, dry place away from direct sunlight; keep bottle tightly capped after use.

Vetrina Setcal Calcium Suspension for Dogs & Cats (200ml)

Vetrina Setcal Suspension is a palatable liquid calcium supplement for dogs and cats, delivering Calcium 400mg, Magnesium 2mg, Vitamin A 4400IU, Vitamin D3 340IU, Vitamin E 16.32mg, and Ascorbic Acid (Vitamin C) 20mg per 10ml — a multi-active formulation supporting calcium absorption, bone mineralisation, musculoskeletal development, and overall vitality. Setcal Suspension is indicated for growing puppies and kittens, pregnant and lactating bitches and queens, large breed dogs, geriatric pets, and animals recovering from fractures or calcium deficiency disorders. Confirm complete composition from the Vetrina Setcal product label.

Composition (per 10ml)

• Calcium — 400mg: The primary macro-mineral for skeletal integrity; 99% of body calcium is stored in bone and teeth as calcium hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂), providing structural rigidity to the skeleton; the remaining 1% in blood and soft tissues is essential for muscle contraction (Ca²⁺-troponin C interaction for actin-myosin cross-bridge formation), neuromuscular transmission (voltage-gated Ca²⁺ channel-mediated neurotransmitter vesicle exocytosis at the neuromuscular junction), cardiac rhythmicity (pacemaker depolarisation and myocardial contraction), blood coagulation (cofactor for clotting cascade factors II, VII, IX, X), and second messenger signalling (calmodulin-mediated intracellular signalling); calcium deficiency (hypocalcaemia) in lactating bitches causes eclampsia (puerperal tetany) — a life-threatening emergency characterised by hypocalcaemic tetanic seizures, muscle tremors, hyperthermia, and cardiovascular collapse; in growing puppies and kittens, dietary calcium deficiency causes nutritional secondary hyperparathyroidism (NSHP) — PTH-driven bone calcium resorption to maintain serum Ca²⁺, resulting in pathological fractures, rubber jaw, and generalised osteoporosis
• Magnesium — 2mg: Essential cofactor for over 300 enzymatic reactions including ATP synthesis (all ATP-dependent reactions require Mg²⁺-ATP complex), DNA and RNA polymerase activity, and protein synthesis; approximately 60% of body magnesium is in bone (as magnesium hydroxyapatite), contributing to bone crystal structure; Magnesium is required for Vitamin D3 activation — both 25-hydroxylation in the liver and 1-alpha-hydroxylation in the kidney (producing calcitriol) require Mg²⁺-dependent hydroxylases; magnesium deficiency impairs Vitamin D3 activation and calcium metabolism
• Vitamin A — 4400 IU: Fat-soluble retinol; essential for bone remodelling (osteoblast and osteoclast regulation via RAR/RXR nuclear receptor signalling), epithelial integrity (skin, GI mucosa, respiratory tract), vision (rhodopsin synthesis), immune function, and reproduction; Vitamin A deficiency impairs bone remodelling and causes periosteal bone overgrowth compressing cranial nerves; Vitamin A toxicity (hypervitaminosis A) in cats causes cervical spondylosis and ankylosis — confirm dose appropriateness with veterinarian for feline patients on Vitamin A-rich diets
• Vitamin D3 (Cholecalciferol) — 340 IU: The critical regulator of calcium and phosphorus homeostasis; Vitamin D3 is hydroxylated in the liver to 25-hydroxycholecalciferol (calcidiol) and then 1-alpha-hydroxylated in the renal proximal tubule to the active hormone calcitriol (1,25-dihydroxycholecalciferol); calcitriol acts via nuclear Vitamin D receptor (VDR) to: (1) upregulate intestinal calcium absorption — inducing TRPV6 calcium channel, calbindin-D9k, and PMCA1b for active transcellular calcium transport in duodenum; (2) upregulate intestinal phosphate absorption — inducing NaPi-IIb cotransporter; (3) stimulate renal calcium and phosphate reabsorption in the distal tubule; (4) stimulate osteoblast differentiation and bone mineralisation; Vitamin D3 deficiency causes rickets in growing animals (failure of osteoid mineralisation — widened growth plates, bowing of long bones, enlarged costochondral junctions/‘rachitic rosary’) and osteomalacia in adults; dogs and cats have limited capacity to synthesise Vitamin D3 from sunlight (limited 7-dehydrocholesterol in skin) and are dietary-dependent for Vitamin D3 — making supplementation particularly important for indoor pets
• Vitamin E (Tocopherol) — 16.32mg: Fat-soluble lipid-soluble antioxidant; protects bone marrow cells, osteoblasts, and musculoskeletal tissue from oxidative damage by reactive oxygen species (ROS); terminates lipid peroxidation chain reactions in cell membranes; essential for muscle function — Vitamin E deficiency causes nutritional muscular dystrophy in dogs (white muscle disease); supports immune function and reproductive health; synergistic with selenium and ascorbic acid for comprehensive antioxidant protection
• Ascorbic Acid (Vitamin C) — 20mg: Water-soluble antioxidant; essential cofactor for prolyl hydroxylase and lysyl hydroxylase — the enzymes that hydroxylate proline and lysine residues in procollagen, forming hydroxyproline and hydroxylysine crosslinks required for stable triple-helical collagen structure; without Vitamin C, collagen is structurally deficient — bone matrix, cartilage, tendons, ligaments, and blood vessel walls are all collagen-dependent; Vitamin C deficiency (scurvy) causes defective bone matrix formation, fracture susceptibility, and poor fracture healing; dogs and cats synthesise Vitamin C endogenously from glucose but supplementation supports tissue repair and antioxidant defence during illness and recovery

Therapeutic Class

• Veterinary multi-active calcium supplement suspension — Calcium + Magnesium + Vitamin A + D3 + E + C — dogs and cats — bone mineralisation, calcium deficiency, pregnancy, lactation, fracture healing, and musculoskeletal development

Indications

• Calcium supplementation in pregnant and lactating bitches and queens — prevention of eclampsia (puerperal hypocalcaemic tetany) and post-whelping calcium depletion
• Bone and skeletal development in growing puppies and kittens — prevention of nutritional secondary hyperparathyroidism (NSHP), rickets, and pathological fractures
• Large breed puppy skeletal development support — appropriate calcium:phosphorus ratio and Vitamin D3 for controlled bone mineralisation
• Calcium deficiency (hypocalcaemia) and related disorders in dogs and cats
• Fracture healing and post-surgical bone recovery — calcium and Vitamin D3 support for callus mineralisation
• Prevention and management of rickets (juvenile), osteoporosis, and osteomalacia in adult and senior dogs and cats
• Musculoskeletal health maintenance in large breed and geriatric dogs

Dosage & Administration

• Puppies & Cats: 2.5ml twice daily
• Adult Dogs: 5ml twice daily
• Pregnant & Lactating Bitches: 10ml twice daily
• Shake well before use; administer orally or mix with food
• Or as directed by a licensed veterinarian

Safety Information

• Do not exceed recommended dose — calcium oversupplementation causes hypercalcaemia, soft tissue and vascular mineralisation, and urolithiasis
• Vitamin D3 toxicity at high doses causes severe hypercalcaemia — do not combine with other Vitamin D3 supplements without veterinary guidance
• Vitamin A toxicity in cats (hypervitaminosis A) causes cervical ankylosis — confirm Vitamin A intake across all dietary sources with veterinarian for feline patients
• Use in large breed puppies should be under veterinary guidance to ensure correct calcium:phosphorus ratio and avoid skeletal developmental disorders (OCD, HOD)
• Store in a cool, dry place; keep cap tightly closed after use; shake well before each use
• Keep out of reach of children