Vetrina Setcoat Syrup for Dogs & Cats 200ml

For use in dogs and cats. Administer as directed. Shake well before use. Keep out of reach of children. Store in a cool, dry place away from direct sunlight; keep bottle tightly capped after use.

Vetrina Setcoat Skin & Coat Conditioner Syrup for Dogs & Cats (200ml)

Vetrina Setcoat Syrup is a comprehensive skin and coat nutritional supplement for dogs and cats, delivering an optimised Omega-6:Omega-3 fatty acid ratio (5:1) alongside antioxidant vitamins and dermatological co-factors in a palatable fish oil-based syrup. Each 5ml provides Linolenic Acid (ALA, Omega-3) 1.46g, Gamma-Linolenic Acid (GLA, Omega-6) 0.03g, Eicosapentaenoic Acid (EPA, Omega-3) 0.18g, Docosahexaenoic Acid (DHA, Omega-3) 0.129g, Vitamin A 460IU, Vitamin E 15.2IU, Vitamin B6 1.1mg, Biotin 48mcg, and Choline 11.6mg — addressing the full spectrum of nutritional causes of excessive shedding, dry skin, dull coat, and nutritional dermatitis in dogs and cats.

Composition (per 5ml)

• Linolenic Acid (Alpha-Linolenic Acid, ALA) — 1.46g: Essential Omega-3 polyunsaturated fatty acid (PUFA); the 18-carbon precursor to the long-chain Omega-3s EPA and DHA via elongase and desaturase enzyme pathways (delta-6-desaturase → delta-5-desaturase); ALA is ‘essential’ — dogs and cats cannot synthesise it de novo and must obtain it from diet; ALA reduces pro-inflammatory arachidonic acid cascade activity by competing with Omega-6 arachidonic acid (AA) for delta-6-desaturase and COX/LOX enzymes, shifting eicosanoid production from pro-inflammatory 2-series prostaglandins (PGE2) and 4-series leukotrienes (LTB4) toward anti-inflammatory 3-series prostaglandins (PGE3) and 5-series leukotrienes (LTB5); reduces skin inflammation, pruritus, and inflammatory dermatitis at the epidermis; incorporated into phospholipid bilayers of skin epidermal barrier cells (keratinocytes), improving transepidermal water loss (TEWL) and skin barrier function
• Gamma-Linolenic Acid (GLA) — 0.03g: Omega-6 PUFA; the direct product of delta-6-desaturase acting on linoleic acid (LA); GLA bypasses the rate-limiting delta-6-desaturase step — providing pre-formed substrate for downstream conversion to dihomo-GLA (DGLA) and then to anti-inflammatory 1-series prostaglandins (PGE1) via COX; DGLA competes with AA at COX, reducing PGE2 production and shifting the eicosanoid profile toward anti-inflammatory mediators; supports skin epidermal barrier lipid synthesis (ceramide and sphingomyelin biosynthesis) and reduces TEWL; GLA deficiency has been associated with seborrhoea, dry scaly skin, and poor coat quality in dogs
• Eicosapentaenoic Acid (EPA) — 0.18g: Long-chain Omega-3 PUFA (20 carbons, 5 double bonds); direct competitive inhibitor of COX-1, COX-2, and 5-LOX acting on arachidonic acid, reducing production of pro-inflammatory PGE2, TXA2 (thromboxane A2), and LTB4; substrate for production of anti-inflammatory eicosanoids — 3-series prostaglandins (PGE3) and 5-series leukotrienes (LTB5); also a precursor to specialised pro-resolving mediators (SPMs) including E-series resolvins (RvE1, RvE2) that actively resolve inflammation by reducing neutrophil influx and promoting macrophage phagocytosis of cellular debris; incorporated into skin keratinocyte membrane phospholipids, improving epidermal barrier integrity; reduces atopic dermatitis, allergic skin disease, pruritus, and inflammatory cytokine (IL-1β, TNF-α, IL-6) production in the skin; fish oil is the direct dietary source of pre-formed EPA (more bioavailable than plant-derived ALA which requires conversion)
• Docosahexaenoic Acid (DHA) — 0.129g: Long-chain Omega-3 PUFA (22 carbons, 6 double bonds); the most structurally important Omega-3 in cell membranes; incorporated into phospholipid bilayers — DHA’s multiple double bonds confer extreme membrane fluidity, essential for normal function of membrane-embedded receptors, ion channels, and transporters; in skin, DHA-enriched keratinocyte membranes have superior barrier function and reduced inflammatory signalling; DHA is also the precursor to protectin D1/neuroprotectin D1 (NPD1) and D-series resolvins (RvD1–RvD6) — anti-inflammatory and pro-resolution SPMs; together with EPA, DHA from fish oil is the primary bioavailable long-chain Omega-3 in Setcoat, as cats have very limited capacity to convert ALA to EPA/DHA (near-absent delta-6-desaturase activity — cats are obligate carnivores requiring pre-formed long-chain Omega-3s from animal sources)
• Vitamin A — 460 IU: Fat-soluble retinol; essential for normal keratinocyte differentiation and skin epidermal turnover; retinoic acid (the active metabolite) binds RAR/RXR nuclear receptors in keratinocytes, regulating genes controlling cell differentiation, proliferation, and apoptosis — maintaining the stratum corneum as a functional skin barrier; Vitamin A deficiency causes follicular hyperkeratosis (rough, scaly skin), seborrhoea, poor coat quality, and impaired wound healing; supports sebaceous gland function for coat lubrication
• Vitamin E (Tocopherol) — 15.2 IU: Fat-soluble lipid-soluble antioxidant; the primary lipid-phase antioxidant in cell membranes; terminates phospholipid peroxidation chain reactions initiated by ROS in keratinocyte and sebocyte membranes — protecting the Omega-3 and Omega-6 PUFAs in Setcoat (which are highly susceptible to oxidative degradation due to their multiple double bonds) from peroxidative destruction; synergistic with Vitamin C (which regenerates oxidised Vitamin E radical back to active tocopherol); Vitamin E deficiency causes increased skin lipid peroxidation, poor coat condition, and immune dysfunction; also supports the anti-inflammatory activity of Omega-3 fatty acids by protecting their structural integrity in cell membranes
• Vitamin B6 (Pyridoxine) — 1.1mg: Water-soluble coenzyme (pyridoxal phosphate/PLP); essential for amino acid metabolism — critically for metabolism of sulphur-containing amino acids (methionine, cysteine) that are the primary building blocks of keratin (the structural protein of hair and coat); supports haem biosynthesis (ALA synthase) and sphingolipid biosynthesis (serine palmitoyltransferase) for skin epidermal barrier ceramide synthesis; Pyridoxine deficiency in dogs causes acrodynia (scaling dermatitis of lips, muzzle, and extremities) and poor coat quality
• Biotin (Vitamin B7/H) — 48mcg: Water-soluble coenzyme for carboxylase enzymes; most directly relevant to coat health as the coenzyme for acetyl-CoA carboxylase (ACC) — the rate-limiting enzyme in de novo fatty acid synthesis; ACC catalyses the carboxylation of acetyl-CoA to malonyl-CoA, the first committed step in fatty acid chain elongation; sebaceous gland lipogenesis (synthesis of sebum — the natural coat lubricant) requires high ACC activity; Biotin deficiency causes seborrhoea, alopecia (hair loss), brittle and dull coat, and scaling dermatitis in dogs and cats; Biotin supplementation is the most directly coat-targeted micronutrient in the Setcoat formulation; also a coenzyme for pyruvate carboxylase (gluconeogenesis) and propionyl-CoA carboxylase (odd-chain fatty acid catabolism)
• Choline — 11.6mg: Essential nutrient; precursor to phosphatidylcholine (the dominant phospholipid of skin keratinocyte cell membranes and sebaceous gland lipids); hepatic phosphatidylcholine synthesis is required for VLDL-mediated export of fatty acids (including the Omega-3 and Omega-6 PUFAs in Setcoat) from the liver to peripheral tissues including skin and hair follicles; choline deficiency impairs hepatic lipid export, reducing PUFA delivery to skin; also a precursor to sphingomyelin (skin epidermal barrier sphingolipid) and acetylcholine (neuromuscular function)

Therapeutic Class

• Veterinary nutritional skin and coat conditioner syrup — Omega-3 (ALA + EPA + DHA) + Omega-6 (GLA) essential fatty acids + Vitamin A + E + B6 + Biotin + Choline — dogs and cats — excessive shedding, dry skin, dull coat, nutritional dermatitis

Indications

• Excessive shedding and hair fall in dogs and cats — nutritional fatty acid and Biotin deficiency-related
• Dry, flaky, or scaly skin (seborrhoea sicca) and dull, brittle coat from Omega-3/Omega-6/Biotin deficiency
• Nutritional deficiency-related dermatitis — including Vitamin A-responsive dermatosis, Pyridoxine acrodynia, and EFA-deficiency dermatitis
• Atopic dermatitis and allergic skin disease management — Omega-3 EPA/DHA reduce skin inflammatory eicosanoid production and pruritus
• Seasonal shedding — moult support during spring/autumn heavy coat change
• Pregnancy and lactation nutritional support — Omega-3 DHA for foetal neurological development and coat/skin maintenance in lactating bitches and queens
• Puppy and kitten coat and skin development
• General daily skin and coat maintenance for dogs and cats of all ages and breeds

Dosage & Administration

• Puppies & Cats: 2.5ml twice daily
• Adult Dogs: 5ml twice daily
• Pregnant / Lactating Bitches: 10ml twice daily
• Shake well before use; administer orally or mix with food
• Or as directed by a veterinarian

Safety Information

• Generally very well tolerated; GI upset (soft stools) may occur at initiation — introduce gradually if needed
• Store in a cool, dry place away from direct sunlight; keep cap tightly closed after use to prevent oxidation of Omega-3 fatty acids
• Keep out of reach of children