Sihil Tonin Pet Syrup & Drops for Dogs & Cats | Multivitamin Amino Acid Health Tonic | 30ml / 200ml

For use in dogs and cats. Administer as directed by a veterinarian or per label dosage. Keep out of reach of children. Store in a cool, dry place. Shake well before use.

Sihil Tonin Pet Syrup & Drops | Multivitamin & Amino Acid Health Tonic for Dogs & Cats

Sihil Tonin by Sihil Pharma is a comprehensive vitamin, micronutrient, and amino acid health tonic for dogs and cats, available in two formats: Tonin Drops 30ml (for puppies and kittens) and Tonin Syrup 200ml (for adult dogs and cats). Sihil Tonin is formulated to meet the elevated micronutrient demands of growing pets, support pets during recovery from illness or surgery, and maintain overall vitality in healthy adult dogs and cats through daily supplementation. Regular use supports healthy growth and muscle development, improved appetite and digestion, strong immune function, brain and neurological development, and coat and skin health.

Product Variants

• Sihil Tonin Drops — 30ml: Concentrated drop formulation for puppies and kittens; easy-to-dose format for small body weights; dose via dropper directly into mouth or mixed with food
• Sihil Tonin Syrup — 200ml: Palatable liquid syrup for adult dogs and cats; mix into food or administer directly; suitable for all breeds

Key Nutrients & Functional Benefits

• B-complex vitamins (B1 Thiamine, B2 Riboflavin, B3 Niacin, B5 Pantothenic acid, B6 Pyridoxine, B7 Biotin, B9 Folic acid, B12 Cyanocobalamin): B vitamins are water-soluble coenzymes central to energy metabolism — B1, B2, B3, B5 are essential cofactors in glycolysis, the TCA (citric acid) cycle, and oxidative phosphorylation for ATP synthesis; B6 (pyridoxal phosphate — PLP) is the cofactor for over 100 aminotransferase and decarboxylase reactions — essential for amino acid catabolism, neurotransmitter synthesis (serotonin from tryptophan via aromatic L-amino acid decarboxylase, GABA from glutamate via glutamate decarboxylase, dopamine from L-DOPA), and haemoglobin synthesis (ALA synthase for porphyrin ring formation); B12 (cobalamin) is required for methionine synthase (homocysteine → methionine → SAM — the universal methyl donor for DNA, RNA, protein, and phospholipid methylation) and methylmalonyl-CoA mutase (propionate metabolism); B9 (folate) is required as 5,10-methylenetetrahydrofolate for thymidylate synthase (dTMP synthesis for DNA replication) and as 5-methyltetrahydrofolate for homocysteine remethylation; Biotin is the covalently-bound coenzyme of carboxylase enzymes (pyruvate carboxylase — gluconeogenesis, acetyl-CoA carboxylase — fatty acid synthesis, propionyl-CoA carboxylase — branched-chain amino acid catabolism)
• Vitamin A (Retinol/Retinyl esters): Essential fat-soluble vitamin; retinal (the aldehyde form) is the chromophore of rhodopsin and cone opsins in retinal photoreceptors — critical for scotopic (dim-light) and photopic vision; retinoic acid (the acid form) acts as a ligand for nuclear retinoic acid receptors (RARα/β/γ) and retinoid X receptors (RXR) — RAR/RXR heterodimers regulate transcription of genes for epithelial cell differentiation (maintaining respiratory, GI, and urogenital epithelial integrity), immune cell development (T-helper cell, dendritic cell, and IgA-producing B cell differentiation), and embryonic development (limb and organ morphogenesis via Hox gene regulation); cats cannot synthesise vitamin A from β-carotene (absent intestinal β-carotene 15,15’-dioxygenase activity — obligate dietary preformed Vitamin A requirement)
• Vitamin D3 (Cholecalciferol): Fat-soluble prohormone; converted in liver to 25-hydroxycholecalciferol (25-OH-D3) by CYP2R1/CYP27A1, and in kidney to 1,25-dihydroxycholecalciferol (calcitriol — the active hormone) by CYP27B1; calcitriol binds the nuclear vitamin D receptor (VDR — a member of the nuclear receptor superfamily) — VDR/RXR heterodimers regulate transcription of TRPV6 (intestinal Ca2+ absorption channel), calbindin-D9k (intracellular Ca2+ transport protein), TRPV5 (renal tubular Ca2+ reabsorption), and RANKL/OPG ratio (osteoclast/osteoblast balance for bone remodelling); critical for calcium and phosphorus homeostasis and bone mineralisation (hydroxyapatite crystal formation in the osteoid matrix); also modulates innate and adaptive immunity (VDR expressed on macrophages, dendritic cells, T cells, B cells — calcitriol promotes antimicrobial peptide cathelicidin expression and regulates Th1/Th2/Treg balance)
• Vitamin E (α-Tocopherol): Lipid-soluble chain-breaking antioxidant; incorporated into cell membrane phospholipid bilayers and plasma lipoproteins; α-tocopherol donates a hydrogen atom to lipid peroxyl radicals (LOO•) generated by polyunsaturated fatty acid (PUFA) peroxidation initiated by reactive oxygen species (ROS — superoxide, hydroxyl radical, singlet oxygen), terminating lipid peroxidation chain reactions and protecting membrane integrity; the tocopheroxyl radical produced is recycled back to α-tocopherol by Vitamin C (ascorbate) — the tocopherol-ascorbate antioxidant network; supports skin and coat health (sebum lipid antioxidant protection), reproductive health, and immune function (NK cell and T-cell membrane integrity)
• Essential amino acids (Lysine, Methionine, Tryptophan, and others): Lysine is the first-limiting essential amino acid in many cereal grain-based pet diets; critical for collagen crosslinking (hydroxylysine formation by lysyl hydroxylase — requires Vitamin C and Fe2+ as cofactors), carnitine biosynthesis (Lysine + Methionine → ε-N-trimethyllysine → carnitine via BB-butyrobetaine hydroxylase — carnitine is the obligate shuttle for long-chain fatty acid transport across the inner mitochondrial membrane for β-oxidation), and protein synthesis (Lysine is incorporated at particularly high frequency in structural proteins — collagen, myosin, actin); Methionine is the universal initiator amino acid for protein synthesis (start codon AUG) and the precursor of S-adenosylmethionine (SAM — methyl donor for DNA methylation, histone methylation, neurotransmitter methylation, and phosphatidylcholine synthesis via the CDP-choline/Kennedy pathway); Tryptophan is the precursor of serotonin (5-HT — via tryptophan hydroxylase and aromatic L-amino acid decarboxylase), melatonin (via N-acetyltransferase and hydroxyindole-O-methyltransferase), and the NAD+ salvage pathway (via the kynurenine pathway — Tryptophan → kynurenine → quinolinate → nicotinate mononucleotide → NAD+); Taurine (conditionally essential in cats — see above) supports cardiac contractility, retinal integrity, and bile acid conjugation
• Appetite and digestive support: B-vitamin complex (particularly B1, B3, B6) supports gastric acid secretion and digestive enzyme production; improved micronutrient status supports hypothalamic appetite regulation and reduces anorexia associated with micronutrient deficiency states; palatable liquid format increases acceptance in anorexic or convalescent dogs and cats

Indications

• Daily multivitamin and amino acid supplementation for puppies and kittens during rapid growth phases
• Nutritional support for adult dogs and cats on home-cooked or nutritionally incomplete commercial diets
• Recovery support after illness, surgery, or hospitalisation
• Appetite stimulation and nutritional rehabilitation in anorexic or convalescent pets
• Immune system support during seasonal stress, travel, or environmental change
• Coat and skin health maintenance in dogs and cats with dull coat or dry skin

Dosage & Administration

• Tonin Drops 30ml — puppies and kittens: Administer recommended drops directly into mouth or mix into food; dose as per label or veterinary instruction
• Tonin Syrup 200ml — adult dogs and cats: Administer recommended volume by syringe into mouth or mix into food; dose as per label or veterinary instruction
• Shake well before each use
• Adjust dose based on body weight, age, and veterinary guidance

Storage

• Store in a cool, dry place away from direct sunlight
• Keep tightly capped after use; keep out of reach of children