Drools Amourglow Clobetasol, Ofloxacin, Miconazole & Zinc Sulphate Skin Cream for Dogs & Cats | Anti-inflammatory, Antibacterial & Antifungal | 20gm

PRESCRIPTION REQUIRED — For external veterinary use only. Use strictly under the supervision of a licensed veterinarian. Contains Clobetasol Propionate — a potent (Class IV/V) topical corticosteroid; restrict application to localised affected areas only; avoid prolonged use, large-area application, or application under occlusive dressings to prevent systemic corticosteroid absorption, skin atrophy, and HPA axis suppression. Do not use near eyes or on mucous membranes. Do not allow pet to lick treated area. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

Drools Amourglow Clobetasol, Ofloxacin, Miconazole & Zinc Sulphate Skin Cream for Dogs & Cats (20gm)

Drools Amourglow is a prescription veterinary four-way combination topical skin cream for dogs and cats, combining four complementary active ingredients: Clobetasol Propionate (potent corticosteroid — anti-inflammatory and antipruritic), Ofloxacin (broad-spectrum fluoroquinolone antibacterial), Miconazole Nitrate (imidazole antifungal), and Zinc Sulphate (skin astringent and healing agent). Amourglow is indicated for complex and mixed skin conditions where concurrent inflammation, bacterial infection, and fungal involvement are present, reducing the need for multiple separate topical products. Use strictly under veterinary supervision. Confirm exact percentage concentrations of each active ingredient from the Drools Amourglow product label before use.

Composition

• Clobetasol Propionate — confirm % from label: Halogenated (chlorinated and fluorinated) Class IV/V potent topical corticosteroid (among the most potent topical corticosteroids available); mechanism of action — binds to intracellular glucocorticoid receptors (GR), forming an active GR-ligand complex that translocates to the nucleus and modulates gene transcription; downregulates pro-inflammatory cytokine genes (IL-1, IL-6, TNF-α) and upregulates anti-inflammatory proteins; inhibits phospholipase A2 (via lipocortin/annexin-1 induction), blocking the release of arachidonic acid from cell membrane phospholipids and thereby suppressing the entire arachidonic acid cascade (prostaglandins, leukotrienes, thromboxanes); potently inhibits mast cell degranulation, reducing histamine-driven pruritus; vasoconstrictive activity reduces erythema and dermal oedema; Clobetasol Propionate's high potency makes it highly effective for rapid relief of severe inflammation and intense pruritus, but mandates restricted, short-duration, localised application in veterinary patients to prevent systemic corticosteroid adverse effects (skin atrophy, adrenal suppression, iatrogenic Cushing's syndrome with prolonged use)
• Ofloxacin — confirm % from label: Second-generation fluoroquinolone broad-spectrum antibacterial; mechanism of action — inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for bacterial DNA supercoiling relief, replication, repair, and transcription; DNA gyrase inhibition causes irreversible double-strand DNA breaks, resulting in rapid bactericidal activity; spectrum — effective against a wide range of Gram-positive (Staphylococcus pseudintermedius, Staphylococcus aureus) and Gram-negative bacteria (Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli) commonly associated with canine and feline pyoderma and secondary bacterial skin infections; topical Ofloxacin provides targeted local antibacterial concentrations at the site of infection
• Miconazole Nitrate — confirm % from label: Imidazole-class antifungal; mechanism of action — inhibits fungal cytochrome P450-dependent 14α-lanosterol demethylase (CYP51), blocking the conversion of lanosterol to ergosterol in the fungal cell membrane biosynthesis pathway; ergosterol depletion and accumulation of toxic sterol intermediates (lanosterol, 14α-methylated sterols) disrupts fungal cell membrane integrity, causing increased membrane permeability, leakage of intracellular components, and fungal cell death; spectrum — active against Malassezia pachydermatis (the predominant yeast causing Malassezia dermatitis in dogs), Microsporum canis (the primary ringworm dermatophyte in dogs and cats), Trichophyton mentagrophytes, Candida species, and other clinically relevant veterinary dermatophytes and yeasts
• Zinc Sulphate — confirm % from label: Inorganic zinc salt; astringent, antimicrobial-supportive, and skin-healing properties; reduces excessive skin exudate and weeping at inflamed or infected skin sites (astringent activity); mild antimicrobial activity supports the antibacterial and antifungal components; zinc is an essential cofactor for metalloenzymes involved in keratinocyte proliferation, collagen synthesis, and skin barrier repair; supports skin healing and recovery of the stratum corneum barrier following infection and inflammation
• Cream base excipients — confirm from Drools Amourglow product label

Therapeutic Class

• Prescription veterinary four-way topical combination cream — corticosteroid anti-inflammatory + fluoroquinolone antibacterial + imidazole antifungal + zinc skin healing agent for dogs and cats

Indications

• Infected allergic and irritant dermatitis with concurrent bacterial and/or fungal involvement — atopic dermatitis secondary infection with Staphylococcus and Malassezia, flea allergy dermatitis with secondary pyoderma
• Mixed bacterial and fungal skin infections — concurrent Staphylococcal pyoderma and Malassezia yeast overgrowth (a common combined presentation in dogs with skin fold dermatitis, allergic skin disease, and otitis externa)
• Malassezia dermatitis (yeast dermatitis) with secondary bacterial infection and inflammation — Malassezia pachydermatis overgrowth causing erythema, pruritus, seborrhoeic skin changes, and characteristic musty/yeasty odour
• Dermatophytosis (ringworm) — Microsporum canis and Trichophyton spp. skin infections with concurrent inflammation; Miconazole is effective against these dermatophyte species
• Skin fold dermatitis (intertrigo) — facial folds, lip folds, vulval folds, tail folds, and body folds in predisposed breeds; Clobetasol reduces fold inflammation, Ofloxacin treats bacterial fold infection, Miconazole treats yeast fold overgrowth
• Localised pruritic, inflamed, erythematous, or crusted skin lesions with mixed infection — hot spots (acute moist dermatitis) with concurrent bacterial and yeast involvement
• Conditions requiring concurrent anti-inflammatory, antibacterial, and antifungal topical management where single-agent therapy is inadequate

Directions for Use

• For external use only — apply a thin layer to the affected skin area as directed by a licensed veterinarian
• Part the hair coat and clean and dry the affected area before application
• Apply to localised areas only — do not apply to large body surface areas
• Do not allow the pet to lick the treated area — use an Elizabethan collar if licking cannot be prevented; systemic ingestion of Clobetasol may cause corticosteroid adverse effects
• Do not use near the eyes or on mucous membranes
• Frequency and duration of use strictly as directed by veterinarian — Clobetasol Propionate should not be used for prolonged periods; confirm maximum treatment duration from product label and veterinarian

Safety Information

• Prescription veterinary medicine — use under supervision of a licensed veterinarian
• Clobetasol Propionate caution — potent topical corticosteroid; prolonged or extensive application can cause: skin atrophy (thinning, fragility, striae), systemic corticosteroid absorption causing HPA axis suppression, iatrogenic hyperadrenocorticism (Cushing's syndrome), or adrenal crisis on sudden withdrawal; use only as directed and for the minimum effective duration
• Do not combine with other topical or systemic corticosteroids during treatment without veterinary guidance
• Culture and sensitivity testing recommended for recurrent or treatment-resistant bacterial or fungal skin infections
• Not for human use — keep out of reach of children
• Store in a cool, dry place away from direct sunlight; keep tube tightly capped after use