Vivaldis Vetecto Spot On 1400 MG 5 ML for 40-56 KG Dogs | Fluralaner Isoxazoline | Tick & Flea Treatment | Topical Spot-On

VETERINARY PRESCRIPTION RECOMMENDED. FOR EXTERNAL USE IN DOGS ONLY. Apply as directed by a veterinarian. Do not use in cats. Keep out of reach of children. Keep treated dogs away from water for 48 hours post-application. Store away from heat and direct sunlight.

Vivaldis Vetecto Spot On for Dogs | Fluralaner Isoxazoline Topical Ectoparasiticide

Vivaldis Vetecto Spot On is a topical ectoparasiticide for dogs containing Fluralaner — an isoxazoline-class systemic insecticide and acaricide. Fluralaner is absorbed dermally and distributes systemically via the bloodstream, killing ticks and fleas when they bite the treated dog. A single monthly spot-on application provides sustained protection against tick and flea infestations. This 5 ml pipette (1400 mg Fluralaner) is size-appropriate for large dogs weighing 40 to 56 kg.

Composition

• Fluralaner 1400 mg per 5 ml pipette (%w/v as per label)
• Excipients: topical solution base (as per label)

Drug Class

• Veterinary topical ectoparasiticide — Isoxazoline class — Fluralaner — systemic insecticide and acaricide — tick and flea treatment and prevention — dogs

Mechanism of Action

• GABA-gated and glutamate-gated chloride channel antagonism (invertebrate-selective): Fluralaner potently antagonises GABA-gated chloride channels and glutamate-gated chloride channels in invertebrate nervous systems, causing sustained membrane depolarisation, uncontrolled neuronal excitation, paralysis, and death of the ectoparasite. Selectivity for invertebrate vs. mammalian GABA-A receptors provides the safety margin in dogs.
• Systemic distribution following dermal absorption: Following spot-on application at the base of the skull/back of neck, Fluralaner is absorbed transdermally and distributed systemically via plasma. It achieves plasma concentrations sufficient to kill Ixodes, Rhipicephalus, Haemaphysalis, and Amblyomma ticks within 12–48 hours of attachment and Ctenocephalides fleas within 8–12 hours. The long plasma half-life maintains ectoparasiticidal concentrations for the full 30-day inter-application interval.
• Spectrum of activity — ticks: Ixodes ricinus and Ixodes scapularis, Rhipicephalus sanguineus (primary tick species in India), Amblyomma americanum, Haemaphysalis spp.
• Spectrum of activity — fleas: Ctenocephalides felis (cat flea — primary flea species infesting dogs in India) and Ctenocephalides canis (dog flea)

Indications

• Treatment and prevention of tick infestations (Ixodes, Rhipicephalus, Amblyomma, Haemaphysalis spp.) in dogs weighing 40 to 56 kg
• Treatment and prevention of flea infestations (Ctenocephalides felis, C. canis) in dogs
• Prevention of tick-borne diseases (Ehrlichiosis, Babesiosis, Lyme disease, Anaplasmosis) by rapid tick kill before pathogen transmission
• Monthly ectoparasite prevention in large dogs in tick and flea-endemic regions (including India)

Dosage & Application

• Topical spot-on: apply entire contents of the 5 ml pipette directly to skin at the base of the skull/back of neck
• Part the fur to ensure direct skin contact; do not apply to broken, inflamed, or irritated skin
• Apply once monthly; do not bathe or allow swimming for 48 hours post-application
• For dogs weighing 40 to 56 kg only — confirm weight-appropriate pipette size with a veterinarian

Contraindications & Safety

• Do not use in cats — formulated for dogs only
• Do not use in puppies under 8 weeks of age or under 2 kg body weight
• Use with caution in dogs with a history of seizures or neurological disorders
• Use with veterinary caution in MDR1/ABCB1-deficient breeds (Collies, Australian Shepherds, Shelties, Border Collies, Whippets)
• Avoid contact with eyes and mucous membranes during application
• Keep treated dogs away from natural water bodies for 48 hours post-application
• Store in a cool, dry place away from heat, flame, and direct sunlight