VETERINARY PRESCRIPTION REQUIRED. For use in cats only. Administer strictly as directed by a veterinarian. Do not use in dogs. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
Vivaldis Robenatail 6mg Tablets for Cats | Robenacoxib COX-2 Inhibitor NSAID
Vivaldis Robenatail 6mg is a veterinary prescription NSAID tablet for cats, containing Robenacoxib 6mg — a highly selective COX-2 inhibitor developed specifically for feline use. The 6mg strength is indicated for smaller cats and for dose titration as directed by a veterinarian. Robenatail 6mg is used for the treatment of acute pain, inflammation, and fever associated with musculoskeletal disorders, soft tissue injuries, and post-operative recovery in cats. Robenacoxib’s tissue-preferential pharmacokinetics — high inflammatory exudate concentration with rapid plasma clearance — provide effective targeted analgesia with reduced systemic NSAID exposure compared to non-selective NSAIDs.
Composition
- Robenacoxib: 6mg per tablet
- Excipients: as per label
Drug Class
- Veterinary NSAID — Selective COX-2 Inhibitor (Coxib class) — Robenacoxib 6mg — analgesic, anti-inflammatory, antipyretic — cats
Mechanism of Action
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COX-2 selective inhibition: Robenacoxib selectively inhibits cyclooxygenase-2 (COX-2), the inducible isoform upregulated at sites of tissue injury and inflammation, while sparing COX-1 (the constitutive isoform responsible for gastric mucosal protection, renal autoregulation, and platelet aggregation); COX-2 converts arachidonic acid to PGH2, which is converted to PGE2 at inflammatory sites; PGE2 sensitises peripheral nociceptors and acts on the hypothalamic thermoregulatory centre to produce fever; Robenacoxib blockade of COX-2 reduces PGE2 synthesis → analgesia and antipyresis with a reduced risk of COX-1-mediated GI and renal adverse effects
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Tissue-preferential pharmacokinetics: Robenacoxib distributes preferentially into inflammatory exudate with a prolonged exudate half-life (≈4 hours in cats) relative to plasma half-life (≈1–2 hours); effective anti-inflammatory drug levels are maintained at inflamed tissue sites longer than in systemic circulation, supporting once-daily dosing at 1mg/kg and contributing to the short systemic exposure and safety profile
Indications
- Acute musculoskeletal pain and inflammation in cats
- Post-operative pain and inflammation following soft tissue or orthopaedic surgery in cats
- Fever (pyrexia) associated with acute inflammatory conditions in cats
- Acute synovitis, arthralgia, and traumatic soft tissue injuries in cats
Dosage & Administration
- Recommended dose: 1mg/kg body weight orally once daily for up to 3 days
- Strip of 10 tablets
- Administer on an empty stomach or with a small amount of food
- Prescription required — administer strictly as directed by a veterinarian
Contraindications & Safety
- Do not use in dogs — for cats only
- Do not use in cats with GI ulceration, renal insufficiency, hepatic impairment, or cardiac failure
- Do not use concurrently with other NSAIDs, corticosteroids, or nephrotoxic drugs
- Do not use in pregnant, lactating, or breeding cats
- Ensure fresh drinking water is always available during treatment
- Monitor renal function in cats on extended or repeated therapy