VetPlus Calmex On The Move for Dogs & Cats | Rose, Lavender & Chamomile Essential Oil Travel Calming | Anxiety Relief for Car Travel, Vet Visits & Transport | 10 & 20 Pack

FOR ANIMAL USE ONLY — Use as directed by a veterinarian or as per label instructions. Calmex On The Move is a veterinary aromatherapy calming product — not a veterinary medicine. For animals with severe travel phobia, severe motion sickness, or extreme aggression in the car, veterinary assessment is recommended; pharmacological interventions (acepromazine is now contraindicated in travel anxiety due to sensory dissociation without anxiolysis; modern evidence-based pharmacological options include maropitant [Cerenia] for motion sickness-associated vomiting, trazodone, gabapentin, or lorazepam for acute travel anxiety under veterinary prescription) may be required alongside or instead of aromatherapy calming. Ensure adequate ventilation in the car during product use. Do not allow direct contact between the essential oil and pet skin or mucous membranes. In homes with birds, use with caution — consult a veterinarian before using any essential oil product near pet birds. Keep out of reach of children and animals.

VetPlus Calmex On The Move for Dogs & Cats | Rose, Lavender & Chamomile Essential Oil Travel Calming | Anxiety Relief for Car Travel, Vet Visits & Transport | 10 & 20 Pack

VetPlus Calmex On The Move is a veterinary aromatherapy travel calming product manufactured by VetPlus Ltd (UK), specifically designed to support dogs and cats during the acute stress of car travel, veterinary clinic visits, transport, and other short-duration situational anxiety events. Calmex On The Move delivers the same VetPlus-developed essential oil blend — Rosa damascena (Rose), Lavandula angustifolia (True Lavender), and Matricaria recutita (German Chamomile) — as the Calmex Plug-In Diffuser, but in a portable, travel-format application (wipe/sachet) for use in the car, pet carrier, or transport crate. This makes it the on-the-go and event-specific product in the Calmex range — where the Plug-In Diffuser provides continuous home environmental calming, Calmex On The Move provides targeted calming for transport and clinic situations. Available in 10-pack and 20-pack.

Travel & Transport Anxiety in Dogs & Cats: Neuroanatomy and Physiology

• The neuroscience of travel anxiety — why car journeys are a unique multi-modal stressor: car travel generates a convergent multi-sensory anxiety stimulus that is uniquely challenging for dogs and cats: (a) vestibular system activation — the car’s acceleration, deceleration, cornering, and road vibration continuously stimulate the vestibular apparatus (semicircular canals — angular acceleration via cupula deflection; otolith organs — utricle and saccule detecting linear acceleration and gravity); the feline and canine vestibular system projects via the vestibular nuclei (medulla oblongata) to the cerebellum, thalamus, and the amygdala (via the central nucleus of the amygdala — CeA); vestibular conflict (mismatch between visual input — moving visual field in the car vs proprioceptive input — static body position on the car seat) activates the area postrema (the blood-brain-barrier-free chemoreceptor trigger zone — CTZ — in the medulla oblongata; the primary site for emesis induction; area postrema neurons express dopamine D2, serotonin 5-HT3, histamine H1, and neurokinin-1 [NK-1 — substance P] receptors) and the nucleus tractus solitarius (NTS) → vomiting centre activation → motion sickness emesis in dogs (the primary clinical presentation) and cats (less common emesis, more common hypersalivation and hypersalivation); (b) olfactory disruption — the car environment presents novel, unpredictable, and aversive olfactory stimuli (exhaust fumes, unfamiliar human scents, other animal scents on car upholstery) to the canine (300 million ORNs, 811 functional OR genes) and feline (200 million ORNs, 750 OR genes) olfactory systems → direct olfactory bulb → piriform cortex → amygdala projection activating BLA fear circuits without thalamic relay; (c) auditory stressors — engine noise, road noise, traffic, and sudden horn/emergency vehicle sounds activate the auditory cortex → inferior colliculus → medial geniculate nucleus (thalamus) → BLA ’low road’ rapid auditory fear conditioning; (d) classical conditioning — dogs and cats rapidly associate the sight of the car, the car carrier, or the vet clinic carpark with previously aversive experiences (injections, examinations, other animals) via BLA NMDA receptor-dependent LTP (fear memory encoding) → anticipatory anxiety beginning before the car journey (at leash retrieval or carrier appearance); (e) social/confinement stress — confinement in a carrier or seatbelt harness restricts the animal’s normal escape and freeze/flight responses → frustration-induced anxiety amplification via the medial prefrontal cortex (mPFC) failure to exert top-down inhibitory control over the BLA; the convergent multi-modal stress of car travel explains why travel anxiety is often more severe than home-based anxiety and why even animals that respond well to home calming (Calmex Diffuser) may require additional targeted intervention for travel
• Olfactory calming during travel — why essential oil aromatherapy is the appropriate route for travel anxiety: the olfactory system’s direct limbic projection (olfactory bulb → piriform cortex → entorhinal cortex → amygdala, bypassing the thalamic relay required by all other sensory modalities) enables olfactory stimuli to modulate amygdalar fear activity rapidly and directly; in the car environment, Calmex On The Move’s rose, lavender, and chamomile essential oil blend disperses into the enclosed car atmosphere → concentrations of linalool, citronellol, geraniol, bisabolol, apigenin, and chamazulene accumulate in the car air → detected at high sensitivity by the canine and feline olfactory systems → direct olfactory-amygdala signalling → BLA fear circuit modulation via: (a) GABA-A PAM activity (citronellol, geraniol, linalool, bisabolol, apigenin) → increased GABAergic inhibitory tone → reduced BLA excitatory output; (b) VGCC inhibition (linalool → N-type CaV2.2 and P/Q-type CaV2.1 inhibition → reduced glutamate/substance P/noradrenaline release at excitatory BLA and locus coeruleus synapses); (c) NMDA receptor antagonism (linalool) → reduced fear memory LTP reconsolidation during the travel event; (d) 5-HT1A partial agonism (geraniol, citronellol) → reduced anxious arousal without sedation; (e) 5-HT2A antagonism (bisabolol) → reduced amygdalar glutamate release; (f) 5-LOX inhibition (chamazulene) → reduced neuroinflammatory LTB4/CysLT1 amygdala hyperactivation; veterinary evidence: Graham et al. (Physiol Behav 2005) — lavender aromatherapy significantly reduced travel-induced excitement and vocalisation in dogs during car journeys; this is the most directly applicable published evidence for the Calmex On The Move indication

Active Essential Oils & Mechanisms (Summary)

• Rosa damascena (Damask Rose) — citronellol, geraniol & phenylethanol: GABA-A PAM at the benzodiazepine binding pocket (α/γ subunit interface) via citronellol and geraniol; 5-HT1A partial agonism (geraniol) → anxiolytic without sedation; 2-phenylethanol CNS depressant via GABA-A potentiation
• Lavandula angustifolia (True Lavender) — linalool & linalyl acetate — the most evidence-based aromatherapy calming oil for travel in companion animals: N-type (CaV2.2) and P/Q-type (CaV2.1) VGCC inhibition (same alpha-2-delta subunit mechanism as pregabalin/gabapentin) → reduced presynaptic glutamate, substance P, and noradrenaline release; NMDA receptor antagonism → reduced fear memory LTP; GABA-A PAM; olfactory-specific mechanism confirmed absent in anosmic animals; Graham et al. (Physiol Behav 2005) — directly demonstrated reduced travel-induced excitement in dogs with lavender aromatherapy
• Matricaria recutita (German Chamomile) — (−)-α-bisabolol, chamazulene & apigenin: bisabolol → 5-HT2A antagonism + GABA-A PAM + NF-κB/IL-1β anti-inflammatory; chamazulene → 5-LOX inhibition + azulene ROS scavenging; apigenin (4′,5,7-trihydroxyflavone) → benzodiazepine site GABA-A partial agonism (Ki ∼4μM); triple GABA-A PAM synergy across three independent binding sites on the GABA-A receptor complex

Indications

• Car travel anxiety — the primary indication; use before and during car journeys for dogs and cats with travel-associated anxiety signs (trembling, salivating, panting, vocalisation, restlessness, attempted escape)
• Motion sickness-associated anxiety — as adjunctive aromatherapy calming alongside veterinary-prescribed anti-emetic medication (maropitant/Cerenia) for dogs with car sickness
• Veterinary clinic and grooming salon visit anxiety — use in the car en route and in the waiting area
• Pet carrier and crate transport anxiety — use in the carrier/crate for airline, train, or long-distance travel
• Short-duration situational anxiety events not suited to continuous diffuser use

Directions for Use

• Use as directed on the product label; apply/place the On The Move product in the car, pet carrier, or transport crate before the journey
• Ensure adequate car ventilation during use
• For best results, allow 10–15 minutes for the aromatic environment to establish before the animal enters the vehicle or carrier
• Do not allow direct contact between the product and the animal’s skin or mucous membranes
• Available in 10-pack (for occasional travel) and 20-pack (for frequent travellers)

Safety Information

• For animals with severe travel anxiety, motion sickness, or extreme behaviour, consult a veterinarian for a multimodal management plan including pharmacological options
• Do not use in cars or spaces with birds or avian pets without veterinary guidance
• Keep out of reach of children and animals; store in a cool, dry place away from direct sunlight