Oriheal Petopenem Meropenem Veterinary Carbapenem Antibiotic Injection for Dogs & Cats | Severe Bacterial Infection, Sepsis, UTI, Respiratory & Resistant Organism Infection | 250mg, 500mg & 1g | Veterinary Prescription

Prescription Required — For veterinary use only. Administer strictly under the supervision of a licensed veterinarian. Injectable medicine — for intravenous (IV) or intramuscular (IM) administration by a qualified veterinary professional only. Last-resort antibiotic — WHO Critically Important Antimicrobial (CIA); use only with confirmed bacterial culture, sensitivity, and veterinary prescription. Do not use empirically without microbiological justification.

Oriheal Petopenem Meropenem Veterinary Carbapenem Antibiotic Injection for Dogs & Cats

Oriheal Petopenem is a veterinary prescription injectable antibiotic containing Meropenem, a carbapenem-class beta-lactam antibiotic, manufactured by Oriheal Lifesciences. Meropenem is one of the broadest-spectrum antibiotics available in veterinary medicine, providing activity against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria, including multidrug-resistant (MDR) organisms such as extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter spp. It is reserved for the treatment of severe, life-threatening, or multidrug-resistant bacterial infections in dogs and cats where first- and second-line antibiotics have failed or are contraindicated based on culture and sensitivity results. Available in three strengths: 250mg, 500mg, and 1g vials.

Composition (per vial)

• Petopenem 250mg: Meropenem (as Meropenem trihydrate) — 250mg per vial
• Petopenem 500mg: Meropenem (as Meropenem trihydrate) — 500mg per vial
• Petopenem 1g: Meropenem (as Meropenem trihydrate) — 1000mg (1g) per vial
• Sodium carbonate (as solubiliser) — confirm from label; reconstitute with sterile water for injection or sodium chloride 0.9% as directed

Mechanism of Action

• Meropenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking and causing rapid bacterial cell lysis and death
• Carbapenem ring structure confers resistance to hydrolysis by most beta-lactamases, including ESBLs and AmpC beta-lactamases — effective where other beta-lactams fail
• Bactericidal against both Gram-positive and Gram-negative organisms including many MDR strains

Therapeutic Class

• Veterinary carbapenem beta-lactam antibiotic (WHO Critically Important Antimicrobial — last-resort class) prescription injection for dogs and cats — severe, life-threatening, and multidrug-resistant bacterial infections

Key Benefits

• Ultra-broad spectrum — active against Gram-positive, Gram-negative, and anaerobic bacteria including MDR organisms (ESBL-producing Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter spp., Klebsiella pneumoniae)
• Carbapenem stability — resistant to hydrolysis by most beta-lactamases; active where extended-spectrum penicillins, cephalosporins, and fluoroquinolones have failed
• Bactericidal action — rapid bactericidal activity with time-dependent pharmacodynamics
• Three strengths available — 250mg, 500mg, and 1g vials allow precise weight-based dosing across small and large breed patients

Indications

• Severe or life-threatening bacterial infections in dogs and cats where culture and sensitivity confirm Meropenem as the appropriate antibiotic
• Multidrug-resistant (MDR) bacterial infections — ESBL-producing Enterobacteriaceae, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter spp.
• Sepsis and bacteraemia in critically ill dogs and cats
• Severe urinary tract infections (UTI) and pyelonephritis with resistant organisms
• Severe respiratory tract infections — pneumonia, pleuropneumonia with MDR pathogens
• Post-surgical and hospital-acquired infections with documented MDR organisms
• Severe wound, abscess, and soft tissue infections unresponsive to first- and second-line antibiotics

Directions for Use

• Administer by intravenous (IV) infusion or intramuscular (IM) injection as directed by a licensed veterinarian
• Reconstitute with sterile water for injection or 0.9% sodium chloride as per label instructions; administer immediately after reconstitution
• Dosage based on body weight, infection severity, and culture/sensitivity results — refer to veterinary prescription (typical veterinary dose: 8.5–24 mg/kg IV/IM every 8–12 hours; confirm from prescription)
• Complete the full prescribed antibiotic course; do not discontinue early even if clinical signs resolve
• Use only based on confirmed culture and sensitivity results — empirical carbapenem use without microbiological justification is not recommended (antibiotic stewardship)

Safety Information

• Prescription medicine — for veterinary use only; IV/IM administration by a licensed veterinary professional only
• WHO Critically Important Antimicrobial (CIA) — carbapenems are the last-resort antibiotic class for MDR Gram-negative infections; use only with confirmed culture and sensitivity; antibiotic stewardship is mandatory
• Confirm beta-lactam hypersensitivity (penicillin/cephalosporin) before administration; cross-reactivity with other beta-lactams possible in sensitised animals
• Use with caution in patients with seizure history or neurological disease — carbapenems (particularly imipenem) have been associated with seizures at high doses; Meropenem has lower seizure risk but caution is warranted
• Renal impairment — Meropenem is renally excreted; reduce dose and/or frequency in patients with significant renal insufficiency
• Keep out of reach of children; store unreconstituted vials as directed on label (typically at controlled room temperature); use reconstituted solution immediately or within the stability window stated on label