Bioibérica ProbioPlus Probiotic Sachets for Dogs | Enterococcus faecium + FOS + MOS + Beta-Glucans + Vitamins | Gut Microbiota Immune Support Stool Consistency | 30 Sachets x 2.5g

VETERINARY USE ONLY. For use in dogs. Administer as directed by a veterinarian. Store in a cool, dry place away from direct sunlight. Once opened, consume immediately. Keep out of reach of children.

Bioibérica ProbioPlus Probiotic Sachets for Dogs (30 Sachets × 2.5g)

Bioibérica ProbioPlus is a veterinary probiotic and prebiotic complementary feed for dogs, developed by Bioibérica — a leading Spanish animal health company. Each 2.5g sachet delivers a precisely formulated synbiotic combination of Enterococcus faecium (live probiotic strain), FOS (fructooligosaccharides), MOS (mannanoligosaccharides), beta-glucans, and vitamins. ProbioPlus is indicated to restore intestinal microbiota, support a strong immune system, and improve stool consistency in dogs. Suitable for dogs of all breeds, sizes, and ages including puppies, adults, and senior dogs. 30 sachets per box.

Composition (per 2.5g sachet)

• Enterococcus faecium: Gram-positive lactic acid bacterium; live probiotic strain; primary probiotic active in ProbioPlus (confirm CFU count from label)
• FOS — Fructooligosaccharides: Soluble prebiotic dietary fibre; selectively fermented by Bifidobacterium and Lactobacillus species
• MOS — Mannanoligosaccharides: Prebiotic derived from Saccharomyces cerevisiae yeast cell wall mannoprotein
• Beta-glucanos — Beta-glucans: β-1,3/1,6-glucan immunomodulatory polysaccharide derived from yeast or cereal
• Vitaminas — Vitamins: Confirm specific vitamin blend (likely Vitamins A, C, D, E, B-complex) from label
• Excipientes c.s.p. — Excipients q.s.: Sachet base/carrier; confirm from label

Mechanisms of Action

• Enterococcus faecium — Probiotic Mechanisms: E. faecium is one of the most extensively studied and validated veterinary probiotic strains (SF68 strain widely used in companion animals); mechanisms: (1) competitive exclusion — E. faecium colonises intestinal epithelial adhesion sites, competitively excluding enteric pathogens (E. coli, Salmonella, Clostridium perfringens, Campylobacter) from binding and colonising the mucosa; (2) lactic acid and bacteriocin production — E. faecium produces L-lactic acid (reducing luminal pH, inhibiting acid-sensitive pathogens) and bacteriocins (enterocins — antimicrobial peptides targeting Gram-positive pathogens including Listeria, Staphylococcus, and Clostridium); (3) tight junction reinforcement — E. faecium upregulates expression of tight junction proteins (occludin, claudin-1, ZO-1) at intestinal epithelial cell junctions, reducing intestinal permeability (‘leaky gut’) and preventing bacterial translocation; (4) immune modulation — E. faecium interacts with intestinal dendritic cells and Peyer’s patch macrophages via TLR-2 and NOD2 pattern recognition receptors, promoting tolerogenic immune responses (Treg/IL-10/IL-12 balance) and mucosal IgA secretion; (5) restoration of post-antibiotic dysbiosis — E. faecium is naturally resistant to several antibiotics and survives antibiotic treatment courses, providing a seeding population for microbiome restoration during and after antibiotic therapy
• FOS — Fructooligosaccharides (Prebiotic): FOS are short-chain β-fructose polymers (degree of polymerisation 2–8); selectively fermented by Bifidobacterium longum, B. animalis, Lactobacillus acidophilus, and E. faecium in the large intestine; fermentation produces short-chain fatty acids (SCFA) — principally butyrate, propionate, and acetate; butyrate is the primary energy substrate for colonocytes (large intestinal epithelial cells), supporting colonocyte proliferation, mucosal barrier repair, and anti-inflammatory effects via inhibition of NF-κB and HDAC (histone deacetylase) in colonocytes; FOS increase Bifidobacterium and Lactobacillus relative abundance while reducing Clostridium, Enterobacteriaceae, and Bacteroides populations; FOS also increase faecal water content and stool bulk, improving stool consistency in both constipated and diarrhoeic dogs
• MOS — Mannanoligosaccharides (Prebiotic & Pathogen Blocker): MOS is derived from the outer mannoprotein layer of Saccharomyces cerevisiae yeast cell walls; dual mechanism: (1) pathogen adhesion blocking — type 1 fimbriated enteric pathogens (Salmonella, E. coli) use mannose-binding lectins (FimH adhesin) on their fimbriae to adhere to mannose residues on intestinal epithelial cells; MOS competitively binds to FimH lectins on pathogen fimbriae, blocking their adhesion to the intestinal epithelium and promoting their agglutination and faecal excretion; (2) immune stimulation — MOS binds to macrophage and dendritic cell mannose receptors (CD206, MRC1), activating innate immune responses including phagocytosis and pro-inflammatory cytokine production; MOS also binds and neutralises mycotoxins (aflatoxin B1, zearalenone, ochratoxin A) within the GI lumen
• Beta-glucans (β-1,3/1,6-glucan) — Immunomodulator: Beta-glucans are polysaccharides from the yeast cell wall (β-1,3/1,6-glucan) or cereal grains (oat/barley β-1,3/1,4-glucan); mechanism: beta-glucans bind Dectin-1 (CLEC7A, a C-type lectin receptor on macrophages, neutrophils, and dendritic cells) and complement receptor 3 (CR3/Mac-1, CD11b/CD18) on innate immune cells; Dectin-1 signalling activates the CARD9/Bcl-10/MALT1 complex, leading to NF-κB-mediated upregulation of pro-inflammatory cytokines (IL-1β, IL-6, IL-12, TNF-α) and reactive oxygen species (ROS) production; this ‘primes’ innate immune cells for enhanced pathogen killing; beta-glucans also activate the alternative complement pathway; net effect: enhanced phagocytosis of bacteria, fungi, and parasites; augmented NK cell cytotoxicity; potentiated vaccine immune responses; reduced infection susceptibility

Key Benefits (as stated on label)

• Contributes to restore intestinal microbiota (flora intestinal)
• Favours a strong immune system
• Improves stool consistency

Therapeutic Class

• Veterinary synbiotic (probiotic + prebiotic) complementary feed — Enterococcus faecium + FOS + MOS + beta-glucans + vitamins — gut microbiota restoration, immune support, stool consistency — dogs all breeds and ages — Bioibérica (Spain)

Indications

• Restoration of gut microbiota after antibiotic therapy or GI illness
• Chronic or recurrent diarrhoea and loose stools in dogs
• Post-infectious GI recovery (parvovirus, bacterial enteritis, parasitic infection)
• Gut dysbiosis and microbiome imbalance
• Immune system support and modulation
• Daily gut health maintenance in dogs of all breeds and ages
• Stress-associated GI upset (boarding, travel, dietary change)

Dosage & Administration

• Mix contents of one sachet (2.5g) with food
• Confirm daily dose and duration from product label or as directed by a veterinarian
• 30 sachets per box; once opened consume sachet immediately

Safety Information

• Veterinary use only; for use in dogs
• Generally very well tolerated; mild transient flatulence may occur during first few days of use as gut microbiome adjusts
• Store in a cool, dry place away from direct sunlight; once opened consume immediately
• Keep out of reach of children